Action potential conduction between a ventricular cell model and an isolated ventricular cell

A survey on linear relations between main electrical components during action potential in ventricular cell

The action potential in a cell is generated as a result of microscopic nonlinear and complex interactions between several components. In our research we found some approximately linear relationships between these components. This finding could lead to better understanding and simpler modeling of the effect of different ionic concentrations on cellular activity. 2006 Elsevier Inc. All rights res...

A Dynamic Model of the Cardiac Ventricular Action Potential

The action potential model presented in our accompanying article in this journal is used to investigate phenomena that involve dynamic changes of [Ca2"]j, as described below. Delayed afterdepolarizations (DADs) are induced by spontaneous Ca'+ release from the sarcoplasmic reticulum (SR), which, in turn, activates both the Na+-Ca'+ exchanger (INaCa) and a nonspecific Ca'+-activated current (Ins(...

Aberrant ventricular conduction and ventricular ectopy.

Electrical interactions between a real ventricular cell and an anisotropic two-dimensional sheet of model cells.

We have extended our "coupling clamp" technique, in which we couple a real cell to a real-time simulation of a model cell, to now incorporate a real cardiac cell as the central element of a two-dimensional sheet of model cells, in which the coupling conductances may be different in the x and y directions and a specific region of lack of coupling conductance may serve as a resistive barrier. We ...

Conduction between isolated rabbit Purkinje and ventricular myocytes coupled by a variable resistance.

Conduction at the Purkinje-ventricular junction (PVJ) demonstrates unidirectional block under both physiological and pathophysiological conditions. Although this block is typically attributed to multidimensional electrotonic interactions, we examined possible membrane-level contributions using single, isolated rabbit Purkinje (P) and ventricular (V) myocytes coupled by an electronic circuit. Wh...